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Isolation and identification of active principles regulating aspects of molt, metabolism and hydromineral balance in Invertebrates. Discovered an active principle in central nervous system of crustaceans that regulates sodium outfulx. The comparative study revealed interesting information in regard to evolution of endocrine mechanisms in Invertebrates and the mode and site of action of some of these hormones.
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Expertise in the field of Animal Physiology with special reference
to neuroendocrine regulation is extended to toxicological aspects
of Environ-mental Biology. Efforts are made to develop diagnostic
tools to assess the impact of pesticide and heavy metal pollution
on the physiology of organisms. Haematology of fish appears to
provide such a prospect. .
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Comparative evaluation of the impact of pesticides on organisms of
rice field ecosystem (fish, crab,snails) with special reference to
physiological, histological and biochemical responses yielded
useful
information in regard to recovery potential of the organisms
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Work on development of a sensitive bioassay through determination
of state of condensation of chromatin and pattern analysis of
nuclei with the aid of Image Analysis for establishing the so
called 'no effect dose' of xenobiotics is in progress. Implication
of altered synthesis of glycosaminoglycans and collagen in
glomerular basement membrane has been demonstrated in rats in
association with Dr. A.S.Reddi of UMDNJ in initiation and
progression of renal disease in relation to diabetes &
hypertension. Participated in biomedical programme relating use of
anti TNF alpha antibodies leading to remission of psoriasis in
human volunteers.
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collaborating with Dr.A.B.Gottlieb. Research is in progress to
develop low cost diagnostic kits to detect chemical and biotoxins
in the environment.
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Providing leadership to monitoring biodiversity,Coastal
afforestation with special reference to mangroves.
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Screening of candidate species of plants to serve as hyper
accumulators of heavy metals such as Chromium, Lead, Cadmium from
soil and water is in progress funded by UGC and INSA.
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